The secret of life, part 2: the solution of the protein folding problem.

Figure 1: Schematic of organisational layers of biology until now, using human as an example. Despite knowing the complete human genome sequence our inability to predict protein structure has severely limited our ability to infer higher organisational layers directly (red). Advances have instead depended on inference from other intermediate data source (blue)
Figure 2: Schematic of organisational layers of biology post CASP14, using human as an example. Accurate structure prediction allows improved direct inference of higher organisational layers of biology (red), reducing depended on inference from other intermediate data source (blue). Improved mechanistic models improves ability to interpret the clinical consequences of genome sequence variants in individuals (green).

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